Day 1 – Wednesday, January 18, 2023
Mechanisms of Resistance and Drug Discovery
7:30-8:30 Career Mentoring: Women in Microbiology and Infectious Diseases (Event Hall)
Helen Boucher, MD
Tufts University, Boston, MA
Sara Cosgrove, MD, PhD
Johns Hopkins University, Baltimore, MD
Robin Patel, MD
Mayo Clinic, Rochester, MN
8:30-8:35 Welcome
Cesar A. Arias, MD, PhD
Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
Suzanne Tomlinson, PhD, MBA
Gulf Coast Consortia
8:35-9:00 Antimicrobial Resistance in the 21st Century: Trials and Tribulations
Helen Boucher, MD
Tufts University, Boston, MA
Session 1
Conveners: Julian Hurdle, PhD, Texas A&M Health Science Center
9:00-9:25 Mechanisms of Cell Envelope Defense Against Antibiotics in Gram-positive Bacteria
William Miller, MD
Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
9:25-9:50 Tracking Emerging Mechanisms of Resistance with Genomics
Francois Lebreton, PhD
Walter Reed Army Institute of Research, Washington, DC
9:50-10:15 Heteroresistance in Gram-negative Bacteria
David Weiss, PhD
Emory University, Atlanta, GA
10:15-10:45 Break and Vendor Show
Session 2 T32 Trainee Symposium: Texas Medical Center Training Program on Antimicrobial Resistance (TP-AMR), Emory Training Program on Antimicrobial Resistance, University of Pittsburgh Training Program on Antimicrobial Resistance
Conveners: Taryn Eubank, PharmD, University of Houston (GCC-TPAMR), Houston, TX
Madison Stellfox, MD, PhD, University of Pittsburgh, Pittsburgh, PA
10:45-11:00 Dissecting the Mechanism of Cell Membrane Adaptation Against Antimicrobials
Kara Hood, PhD
Houston Methodist Research Institute (GCC-TP-AMR), Houston, TX
11:00-11:15 Kip Proteins Promote Clostridoides difficile Growth in Bile Salts
Cheyenne Lee
Emory University, Atlanta, GA
11:15-11:30 Pathogenesis, Localization and Host Response During Influenza and Streptococcus Pneumoniae Co-infection in Ferrets
Janie French
University of Pittsburgh, Pittsburgh, PA
11:30-11:45 Prospective Assessment of TonB Receptor Mutants and Cefiderocol Susceptibility Across Clinical Isolates of Pseudomonas Aeruginosa
Stephanie Egge, MD
Houston Methodist Research Institute (GCC-TP-AMR), Houston, TX
11:45-11:50 Introduction to Keynote
Natasha Kirienko, PhD
Rice Univ.
11:50-12:20 Keynote Lecture
Drug Efflux in Gram-negative Bacteria
Helen I. Zgurskaya, PhD
University of Oklahoma, Norman, OK
12:20-2:00 Lunch/Rapid Fire/Poster session (Event Hall)
12:20 pick up lunch
12:35-1:05 Rapid Fire presentations:
Investigation of Fecal pH in Healthy Volunteers Receiving Oral Omadacycline or Vancomycin
Samantha Agyapong, Univ. of Houston
Real-world Clinical Outcomes of Cefiderocol Therapy in the Veterans Health Administration
Eva Amenta, Baylor College of Medicine
High Throughput Screen of Group A Streptococcus Clinical Isolates to Identify Conserved Strain-Specific Polymorphisms in Two-Component Systems Associated with Susceptibility to Membrane-Targeting Antimicrobials
Dalton Bui, McGovern Medical School
Machine Learning Text Mining for Carbapenemase-Producing Organisms and Susceptibility Testing Results for Ceftazidime/avibactam & Ceftolozane/tazobactam
Andrew Chou, Baylor College of Medicine
Vancomycin-Resistant vanB- and vanA/vanB-type Enterococcus faecium Causing Invasive Infections in Adult Patients in Chile (2018-2022)
Lorena Diaz, Clínica Alemana – Universidad del Desarrollo
Simulated Human Dosing of Ceftazidime in a Murine Pneumonia Model
Brianna Eales, University of Houston
1:05-2:00 Poster Session, posters 1-26
Session 3
Conveners: Tim Palzkill, PhD, Baylor College of Medicine, Houston, TX
Cecilia Tran, PharmD, Houston Methodist Research Institute, Houston, TX
2:00-2:25 Mechanisms of Resistance to Novel B-lactam/B-lactam Inhibitors
Laurent Poirel, PhD
University of Fribourg, Switzerland
2:25-2:50 Environmental Contamination and the Evolution of MRSA in Latin America
Jose M. Munita, MD
Clinica Alemana and Universidad del Desarrollo, Santiago, Chile
2:50-3:15 Novel Insights into Daptomycin Resistance in Staphylococcus aureus
Adriana Rosato, PhD
Maine Health Institute for Research
3:15-3:30 Break
Session 4 NIH Antimicrobial Resistance Leadership Group (ARLG) Early stage investigators
Conveners: Vance Fowler, MD MPH, Duke University, Durham, NC
Anthony Harris, MD., University of Maryland, Baltimore, MA
NIH Antimicrobial Resistance Leadership Group (ARLG) – Early stage investigators
3:30-3:45 Complicated Intra-abdominal Infection Trials: FDA Geographic Variation
Tori Kinamon, MD
Duke University, Durham, NC
3:45-4:00 A ZEPHYR in the DOOR: Reanalysis of a Controversial Trial
Jess Howard-Anderson, MD
Emory University, Atlanta, GA
4:00-4:15 Making the SCENE: Interim Results from the SCENE StudyMichael Satlin, MD
Weill Cornell Medical College, New York, NY
4:15-4:30 Carbapenem-Resistant E. coli from CRACKLE
Angelique Boutzoukas, MD
Duke University, Durham, NC
Session 5 Selected Abstracts
Convener: Sam Shelburne, MD, PhD, UT MD Anderson Cancer Center, Houston, TX
Natasha Kirienko, PhD, Rice University, Houston, TX
4:30-4:45 GENO-STELLAR: A Clinically Actionable Tool for Identifying Anti-Microbial Resistant Klebsiella pneumoniae Species
Hossaena Ayele, UT Health Science Center Houston
4:45-5:00 Clonal Dynamics of Methicillin-Resistant Staphylococcus aureus in a Tertiary Healthcare Center Between 2000-2016 in Chile
Jose RW Martinez, Universidad del Desarrollo
5:00-5:15 Phosphorodiamidate Morpholino Oligomers Targeting acpP Reduce the Biofilm Burden in Burkholderia cepacia Complex
Antonio Mendez, Univ. of Texas Southwestern
Day 2 – Thursday, January 19, 2023
Translational and Clinical Aspects of Antibiotic Resistance
7:30-8:30 Career Mentoring: Careers in Computational Genomics Applied to Infectious Diseases (Event Hall)
Todd Treangen, PhD
Rice Univ., Houston, TX
Blake Hanson, PhD
Univ. of Texas Health Science Center, Houston, TX
Nadim Ajami, PhD,
MD Anderson Cancer Center, Houston, TX
Lee Harrison, MD
University of Pittsburgh
Session 6
Conveners: Tor Savidge, PhD, Baylor College of Medicine, Houston, TX
Blake Hanson, PhD, University of Texas Health Science Center at Houston
8:30-8:55 Targeting Cell Envelope in Gram-negative Bacteria
Anna Konovalova, PhD
Univ. of Texas Health Science Center, Houston, TX
8:55-9:20 Shoving the Envelope: Towards Point-of-care Characterization of Antimicrobial Resistance and Emerging Pathogens with SeqScreen
Todd Treangen, PhD
Rice Univ., Houston, TX
9:20-9:45 Genomic Insights into Local Persistence and Global Spread of Antibiotic Resistance
Ashlee Earl, PhD
Broad Institute, Boston, MA
9:45-10:15 Vendor Show and Networking
Session 7 T32 Trainee Symposium: Texas Medical Center Training Program on Antimicrobial Resistance (TP-AMR), Emory Training Program on Antimicrobial Resistance, University of Pittsburgh Training Program on Antimicrobial Resistance
Conveners: Cheyenne Lee, Emory University, Atlanta, GA
Kara Hood PhD, Houston Methodist Research Institute (GCC-TPAMR), Houston, TX
10:15-10:30
Elucidation of Molecular Mechanisms Underlying Successful Adaptation to Carbapenem Antimicrobials in High Risk Carbapenem Resistant Escherichia coli Lineages
William Shropshire, PhD
MD Anderson Cancer Center (GCC-TPAMR)
10:30-10:45 Transcriptional Thermoregulation of the Protease PrpL in Pseudomonas aeruginosa
Rachel Done
Emory Univ., Atlanta, GA
10:45-11:00 A Molecular Epidemiological Exploration of Reduced Vancomycin Susceptibility in Clostridioides difficile
Taryn Eubank, PharmD
Univ. of Houston (GCC-TPAMR)
11:00-11:15 Within-host Evolution of Staphylococcus aureus Stringent Response Impart Growth Advantage Under Nutrient Stress
Edwin Chen, PhD
Univ. of Pittsburgh, Pittsburgh, PA
11:15-11:30 Bacteriophage Therapy In Recurrent vancomycin-resistant E. faecium bacteremia
Madison Stellfox, MD, PhD
Univ. of Pittsburgh, Pittsburgh, PA
11:30-11:35 Introduction to Keynote
Julian Hurdle, PhD
Texas A&M Univ.
11:35-12:05 Keynote Lecture
Discovering New Antibiotics from Unlikely Sources
Kim Lewis, PhD
Northeastern Univ., Boston, MA
12:05-2:00 Lunch/Rapid Fire/Poster session (Event Hall)
12:05 pick up lunch
12:20-12:50 Rapid Fire Presentations:
Understanding the Effects of Staphylococcus aureus Urease on Biofilm Production and Antibiotic Recalcitrance in Clinical Isolates
Jana Gomez, Univ. of Texas Health Science Center at Houston
Identifying LiaFSR Residues Contributing to ExPortal Integrity and Response to Antimicrobials in Group A Streptococcus (GAS)
Madeline Guy, McGovern Medical School at University of Texas Health Science Center at Houston
The Effects of Oral Omadacycline and Vancomycin on the Gut Microbiome in Healthy Subjects
Jinhee Jo, University of Houston
Mapping the Determinants of Catalysis and Substrate Specificity of the Antibiotic Resistance Enzyme CTX-M β-lactamase
Allison Judge, Baylor College of Medicine
Activity of Newer Antibiotics Against Carbapenem-Resistant Enterobacterales Isolates – Emory Healthcare, 2016-2021
Christina Lin, Emory School of Medicine
A Retrospective, Observational Study of 12 Cases of Expanded Access Phage Therapy
Austen Terwilliger, Baylor College of Medicine
12:50-2:00 Poster Session, posters 30-52
Session 8
Conveners: Cesar A. Arias MD, PhD, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
2:00-3:00 Challenging Clinical Cases in Antimicrobial Resistance
Andrew Chou, MD, PhD
Baylor College of Medicine, Houston, TX
Sara Cosgrove, MD
Johns Hopkins Univ., Baltimore, MD
Saima Aslam, MD
Univ. of California, San Diego, CA
Session 9 ARLG Session 2
Title: Clinical Research in Antimicrobial Resistance
Conveners: Henry Chambers, MD, University of California San Francisco, San Francisco, CA
Vance Fowler, MD MPH, Duke University, Durham, NC
3:00-3:15 DEI in MRSA Clinical Trials
Melinda Pettigrew, PhD
Yale Univ., New Haven, CT
3:15-3:30 Carbapenemases in XDR Pseudomonas
Michael Satlin, MD
Weill Cornell Medical College, New York, NY
3:30-3:45 “You Don’t Know How It Feels” QOL Assessments by Patients with Complicated Urinary Tract Infections and Their Treating Physicians
Heather King, PhD
Duke Univ., Durham, NC
3:45-4:00 The FAST Study
Ritu Banerjee, MD, PhD
Vanderbilt Univ., Nashville, TN
4:00-4:30 Vendor Show and Networking
Session 10
Conveners: Rodrigo Baptista, PhD, Houston Methodist Research Institute, Houston, TX.
Vincent Tam, PharmD, Univ. of Houston, Houston, TX
4:30-4:55 Deploying new B-lactam/B-lactamase Inhibitors in Clinical Practice
Erin McCreary, PharmD
Univ. of Pittsburgh, Pittsburgh, NC
4:55-5:20 Phage Therapy for Multidrug-resistant Organisms
Saima Aslam, MD
Univ. of California, San Diego, CA
5:20-5:45 Combating Antimicrobial Resistance in Orthopedic Infections
Robin Patel, MD
Mayo Clinic, Rochester, MN
Day 3 – Friday, January 20, 2023
Antibiotic Stewardship
7:30-8:30 Careers in Antibiotic Stewardship (Event Hall)
Ed Septimus, MD
Harvard Medical School
Shivani Patel, PharmD
Houston Methodist Research Institute, Houston, TX
Michael L. Chang, MD
Univ. of Texas Health Science Center, Houston, TX
Session 11
Conveners: Kevin Garey PhD Univ. of Houston College of Pharmacy
Ed Septimus, MD Harvard Medical School
8:30-8:35 Welcome
Ed Septimus, MD
Harvard Medical School and Texas A&M College of Medicine, Houston, TX
8:35-8:55 Notable Collaborative Accomplishment Highlight: Houston Wastewater Surveillance Program
Kathy Ensor, PhD, Rice Univ.
Loren Hopkins, Phd, Houston Health Dept.
David Persse, MD, Houston Fire Dept.
Lauren Stadler, PhD, Rice Univ.
8:55-9:35 Keynote:
Antimicrobial Stewardship in the ICU
Marin Kollef, MD
Washington Univ. School of Medicine, St Louis MO
9:35-10:05 Epidemiology and Management of Carbapenem-Resistant Acinetobacter baumannii (CRAB)
Keith Kaye, MD
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
10:05-10:35 Evolving Clinical Resistance to Novel Agents in Pseudomonas aeruginosa
Ryan Shields, PharmD, MS
Univ. of Pittsburgh, Pittsburgh, PA
10:35-11:05 Vendor show and networking
Session 12
Conveners: Taryn Eubank, PharmD Houston Methodist Research Institute
Robert Atmar, MD Baylor College of Medicine Houston TX
11:05-11:35 Treating Serious Gram-Positive Infections: Resistance, Biofilm, and High Inoculum
Kerry L. LaPlante, PharmD
Brown Univ., Providence, RI
11:35-12:05 A Statewide Registry for MDROs: Illinois’ Experience
William Trick, MD
Rush Univ. Medical Center, Chicago, IL
12:05-12:35 Looking Ahead: β-Lactam Agents on the Horizon Targeting Carbapenem-Resistant Gram-Negative Infections
Pranita Tamma, MD, MHS
John Hopkins Univ. School of Medicine, Baltimore, MD
12:35-2:05 Lunch/Rapid Fire/Poster session (Event Hall)
12:35 pick up lunch
12:50-1:20 Rapid Fire Presentations:
Perspectives on Non-prescription Antibiotic Use Among Hispanic Patients in the Houston Metroplex
Lindsey Laytner, Baylor College of Medicine, Family and Community Medicine
“Evaluation of Cefazolin High Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus (MSSA) Using Gold standard MICs and Rapid Colorimetric Test (RCT)”
Husna Malikzad, Houston Methodist Hospital
Virulence Factors of Multi-drug Resistant Aeromonas Isolates Elucidated Using RNA Sequencing
Blake Neil, University of Texas Medical Branch
CL Synthases Play Redundant Roles and Are Required for Membrane Remodeling in Daptomycin Resistance Enterococcus faecalis
April Nguyen, McGovern Medical School
Simplified Microbial Communities as Antibiotic Alternative in Treatment of Clostridioides difficile Infection
Eva Preisner, Baylor College of Medicine
A Novel Type of Cytotoxic Membrane Vesicles Produced by Pseudomonas aeruginosa
Qi Xu, Rice Univ.
1:20-2:05 Poster Session, posters 60-85
2:05-2:35 CLSI updates: New Year and New Breakpoints
James Lewis, PharmD
Oregon Health & Science Univ., Portland OR
Session 13
Conveners: Yasser Alsafadi, MD Houston Methodist Research Institute
Jinhee Jo, PharmD , Univ. of Houston College of Pharmacy
2:35-3:05 The Long and Short of it: Assessing Antibiotic Durations for Common Pediatric Infections
Michelle Mitchell, MD
Children’s Wisconsin
3:05-3:35 Candida auris
Thomas Patterson, MD
Univ. of Texas Health Science Center San Antonio TX
3:35–4:05 Microbiome Inroads Toward MDRO Decolonization
Michael Woodworth, MD
Emory Univ. School of Medicine, Atlanta GA
4:05 Introduction to Keynote
Ed Septimus, MD Harvard Medical School
4:10-4:40 Closing Keynote
Preparedness for Emerging Pathogens: Are We Ready?
Susan LF McLellan, MD
University of Texas Medical Branch Galveston, TX
4:40 Closing Remarks